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Emergence of high-level colistin resistance mediated by multiple determinants, including mcr-1.1, mcr-8.2 and crrB mutations, combined with tigecycline resistance in an ST656 Klebsiella pneumoniae

Colistin and tigecycline are usually regarded as the last resort for multidrug-resistant Klebsiella pneumoniae infection treatment. Emergence of colistin and tigecycline resistance poses a global healthcare challenge and is associated with high mortality due to limited therapeutic options. Here, we...

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Detalles Bibliográficos
Autores principales: Wang, Yanfei, Zhou, Junxin, Liu, Haiyang, Wang, Qian, Zhang, Ping, Zhu, Jingyi, Zhao, Dongdong, Wu, Xueqing, Yu, Yunsong, Jiang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909390/
https://www.ncbi.nlm.nih.gov/pubmed/36779188
http://dx.doi.org/10.3389/fcimb.2023.1122532