APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice

The Tau protein can be phosphorylated by numerous kinases. In Alzheimer’s disease (AD) hyperphosphorylated Tau species accumulate as neurofibrillary tangles that constitute a major hallmark of AD. AD is further characterized by extracellular Aβ plaques, derived from the β-amyloid precursor protein A...

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Detalles Bibliográficos
Autores principales: Baltissen, Danny, Bold, Charlotte S., Rehra, Lena, Banićević, Marija, Fricke, Justus, Just, Jennifer, Ludewig, Susann, Buchholz, Christian J., Korte, Martin, Müller, Ulrike C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909437/
https://www.ncbi.nlm.nih.gov/pubmed/36779015
http://dx.doi.org/10.3389/fncel.2023.1106176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909437/
https://www.ncbi.nlm.nih.gov/pubmed/36779015
http://dx.doi.org/10.3389/fncel.2023.1106176

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