A novel small positive allosteric modulator of neuropeptide receptor PAC1-R exerts neuroprotective effects in MPTP mouse Parkinson’s disease model: A new drug for Parkinson’s disease

As a neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP)-preferring receptor, PAC1-R mediates effective neuroprotective activity. Based on the finding that the antibiotic doxycycline (DOX) with clinical neuroprotective activity functions as a positive allosteric modulator (PAM) o...

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Detalles Bibliográficos
Autores principales: Fan, Guangchun, Chen, Shang, Tao, Zhengxin, Zhang, Huahua, Yu, Rongjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909460/
https://www.ncbi.nlm.nih.gov/pubmed/36082935
http://dx.doi.org/10.3724/abbs.2022126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909460/
https://www.ncbi.nlm.nih.gov/pubmed/36082935
http://dx.doi.org/10.3724/abbs.2022126

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