Cargando…

Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric Disorders: A Genome-Wide Pleiotropic Analysis

IMPORTANCE: Comorbidities and genetic correlations between gastrointestinal tract diseases and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) hypothesized as a potential biological basis. However, the degree to which the shared genetic determinants are involved in the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gong, Weiming, Guo, Ping, Li, Yuanming, Liu, Lu, Yan, Ran, Liu, Shuai, Wang, Shukang, Xue, Fuzhong, Zhou, Xiang, Yuan, Zhongshang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Medical Association 2023
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909581/ https://www.ncbi.nlm.nih.gov/pubmed/36753304 http://dx.doi.org/10.1001/jamapsychiatry.2022.4974

Ejemplares similares

Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer’s disease and Parkinson’s disease: a large-scale multi-trait association analysis
por: Guo, Ping, et al.
Publicado: (2022)

Likelihood-based Mendelian randomization analysis with automated instrument selection and horizontal pleiotropic modeling
por: Yuan, Zhongshang, et al.
Publicado: (2022)

Integrative Analysis of Transcriptome-Wide Association Study and Gene-Based Association Analysis Identifies In Silico Candidate Genes Associated with Juvenile Idiopathic Arthritis
por: Liu, Shuai, et al.
Publicado: (2022)

Association between obesity indices and type 2 diabetes mellitus among middle-aged and elderly people in Jinan, China: a cross-sectional study
por: Wang, Shukang, et al.
Publicado: (2016)

Association between white blood cell count and non-alcoholic fatty liver disease in urban Han Chinese: a prospective cohort study
por: Wang, Shukang, et al.
Publicado: (2016)

Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis
por: Iriondo-DeHond, Amaia, et al.
Publicado: (2020)

Pleiotropic fitness effects of a Drosophila odorant-binding protein
por: Mokashi, Sneha S, et al.
Publicado: (2022)

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations
por: Fuchs, Helmut, et al.
Publicado: (2016)

Shared Genetic Risk in the Association of Screen Time With Psychiatric Problems in Children
por: Zhang, Yingzhe, et al.
Publicado: (2023)

Evidence for the Accumulation of Nonsynonymous Mutations and Favorable Pleiotropic Alleles During Wheat Breeding
por: Raherison, Elie, et al.
Publicado: (2020)

Meta-analysis identifies pleiotropic loci controlling phenotypic trade-offs in sorghum
por: Mural, Ravi V, et al.
Publicado: (2021)

Pleiotropic Functions of High Fat Diet in the Etiology of Osteoarthritis
por: Asou, Yoshinori, et al.
Publicado: (2016)

Pleiotropic Functions of the Chromodomain-Containing Protein Hat-trick During Oogenesis in Drosophila melanogaster
por: Singh, Ankita, et al.
Publicado: (2018)

The Genetic Architecture of Ovariole Number in Drosophila melanogaster: Genes with Major, Quantitative, and Pleiotropic Effects
por: Lobell, Amanda S., et al.
Publicado: (2017)

Pleiotropic Effects of a Mitochondrial–Nuclear Incompatibility Depend upon the Accelerating Effect of Temperature in Drosophila
por: Hoekstra, Luke A., et al.
Publicado: (2013)

Role of the brain-gut axis in gastrointestinal cancer
por: Di, Yang-Zi, et al.
Publicado: (2019)

Functional Gastrointestinal Disorders with Psychiatric Symptoms: Involvement of the Microbiome–Gut–Brain Axis in the Pathophysiology and Case Management
por: Șchiopu, Cristina Gabriela, et al.
Publicado: (2022)

Clinical Importance of Clonal Hematopoiesis in Metastatic Gastrointestinal Tract Cancers
por: Diplas, Bill H., et al.
Publicado: (2023)

Role of Ectopic Gene Conversion in the Evolution of a Candida krusei Pleiotropic Drug Resistance Transporter Family
por: Lamping, Erwin, et al.
Publicado: (2017)

Complex pleiotropic genetic architecture of evolved heat stress and oxidative stress resistance in the nematode Caenorhabditis remanei
por: O’Connor, Christine H, et al.
Publicado: (2021)

The Microbiota–Gut–Brain Axis in Psychiatric Disorders
por: Góralczyk-Bińkowska, Aleksandra, et al.
Publicado: (2022)

Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis
por: Tesfaye, Markos, et al.
Publicado: (2023)

Perturbations in Gut Microbiota Composition in Psychiatric Disorders: A Review and Meta-analysis
por: Nikolova, Viktoriya L., et al.
Publicado: (2021)

Activation of the Pleiotropic Drug Resistance Pathway Can Promote Mitochondrial DNA Retention by Fusion-Defective Mitochondria in Saccharomyces cerevisiae
por: Mutlu, Nebibe, et al.
Publicado: (2014)

Comprehensive Transcriptional Profiling of the Gastrointestinal Tract of Ruminants from Birth to Adulthood Reveals Strong Developmental Stage Specific Gene Expression
por: Bush, Stephen J., et al.
Publicado: (2018)

Estimated Cost-effectiveness of Endoscopic Screening for Upper Gastrointestinal Tract Cancer in High-Risk Areas in China
por: Xia, Ruyi, et al.
Publicado: (2021)

Gastrointestinal tract (gut) health in the young pig
por: Pluske, John R., et al.
Publicado: (2018)

The Role of Gut Microbiota in Gastrointestinal Tract Cancers
por: Grochowska, Marta, et al.
Publicado: (2022)

The possible role of the Microbiota-Gut-Brain-Axis in the etiology of Major depressive Disorder (MDD) The possible role of the Microbiota-Gut-Brain-Axis in the etiology of Major depressive Disorder (MDD) The possible role of the Microbiota-Gut-Brain-Axis in the etiology of Major depressive Disorder (MDD)
por: Pieters, T., et al.
Publicado: (2022)

Serological Markers Associated With Response to Immune Checkpoint Blockade in Metastatic Gastrointestinal Tract Cancer
por: Lu, Zhihao, et al.
Publicado: (2019)

Evaluation of Racial Disparities in Quality of Care for Patients With Gastrointestinal Tract Cancer Treated With Surgery
por: Bakkila, Baylee F., et al.
Publicado: (2022)

Characteristics and Procedures Among Adults Discharged to Hospice After Gastrointestinal Tract Surgery in California
por: Greenberg, Anya L., et al.
Publicado: (2022)

Phoenixin—A Pleiotropic Gut-Brain Peptide
por: Schalla, Martha A., et al.
Publicado: (2018)

CDH13 promoter SNPs with pleiotropic effect on cardiometabolic parameters represent methylation QTLs
por: Putku, Margus, et al.
Publicado: (2014)

Highly pleiotropic variants of human traits are enriched in genomic regions with strong background selection
por: Novo, Irene, et al.
Publicado: (2021)

CoNet: Efficient Network Regression for Survival Analysis in Transcriptome-Wide Association Studies—With Applications to Studies of Breast Cancer
por: Han, Jiayi, et al.
Publicado: (2023)

Relationship between Lipid Profiles and Glycemic Control Among Patients with Type 2 Diabetes in Qingdao, China
por: Wang, Shukang, et al.
Publicado: (2020)

Metabolomics changes in brain-gut axis after unpredictable chronic mild stress
por: Xu, Qiuyue, et al.
Publicado: (2022)

A novel quantitative body shape score for detecting association between obesity and hypertension in China
por: Wang, Shukang, et al.
Publicado: (2015)

The Effect of Probiotic Supplementation on the Gut–Brain Axis in Psychiatric Patients
por: Sabit, Hussein, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_hcevnic3eprnmm1eug6vb9a7ae