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Extensive accumulation of misfolded protein aggregates during natural aging and senescence

Accumulation of misfolded protein aggregates is a hallmark event in many age-related protein misfolding disorders, including some of the most prevalent and insidious neurodegenerative diseases. Misfolded protein aggregates produce progressive cell damage, organ dysfunction, and clinical changes, whi...

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Detalles Bibliográficos
Autores principales: Cuanalo-Contreras, Karina, Schulz, Jonathan, Mukherjee, Abhisek, Park, Kyung-Won, Armijo, Enrique, Soto, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909609/
https://www.ncbi.nlm.nih.gov/pubmed/36778589
http://dx.doi.org/10.3389/fnagi.2022.1090109