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Construction of Genetically Encoded Biosensors to Monitor Subcellular Compartment-Specific Glutathione Response to Chemotherapeutic Drugs in Acute Myeloid Leukemia Cells

[Image: see text] Glutathione (GSH), the constituent of the redox buffer system, is a scavenger of reactive oxygen species (ROS), and its ratio to oxidized glutathione (GSSG) is a key indicator of oxidative stress in the cell. Acute myeloid leukemia (AML) is a highly aggressive hematopoietic maligna...

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Detalles Bibliográficos
Autores principales: Abbas, Ghulam, Cui, Mengmeng, Wang, Dianbing, Li, Min, Zhang, Xian-En
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909732/
https://www.ncbi.nlm.nih.gov/pubmed/36701391
http://dx.doi.org/10.1021/acs.analchem.2c04255