Cargando…

Unequal distribution of genetically-intact HIV-1 proviruses in cells expressing the immune checkpoint markers PD-1 and/or CTLA-4

INTRODUCTION: HIV-1 persists in resting CD4(+) T-cells despite antiretroviral therapy (ART). Determining the cell surface markers that enrich for genetically-intact HIV-1 genomes is vital in developing targeted curative strategies. Previous studies have found that HIV-1 proviral DNA is enriched in C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fisher, Katie, Schlub, Timothy E., Boyer, Zoe, Rasmussen, Thomas A., Rhodes, Ajantha, Hoh, Rebecca, Hecht, Frederick M., Deeks, Steven G., Lewin, Sharon R., Palmer, Sarah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909745/ https://www.ncbi.nlm.nih.gov/pubmed/36776833 http://dx.doi.org/10.3389/fimmu.2023.1064346

Ejemplares similares

Cellular Activation, Differentiation, and Proliferation Influence the Dynamics of Genetically Intact Proviruses Over Time
por: Horsburgh, Bethany A, et al.
Publicado: (2021)

Markers of Immune Activation and Inflammation Are Associated with Higher Levels of Genetically-Intact HIV in HIV-HBV Co-Infected Individuals
por: Wang, Xiao Qian, et al.
Publicado: (2022)

Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy
por: Sun, Weiwei, et al.
Publicado: (2023)

Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy
por: Sun, Weiwei, et al.
Publicado: (2023)

Intact HIV Proviruses Persist in the Brain Despite Viral Suppression with ART
por: Cochrane, Catherine R., et al.
Publicado: (2022)

Defective proviruses rapidly accumulate during acute HIV-1 infection
por: Bruner, Katherine M., et al.
Publicado: (2016)

Adaptation of Droplet Digital PCR-Based HIV Transcription Profiling to Digital PCR and Association of HIV Transcription and Total or Intact HIV DNA
por: Tumpach, Carolin, et al.
Publicado: (2023)

Memory CD4(+) T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency
por: Rasmussen, Thomas A., et al.
Publicado: (2022)

Relationship between intact HIV-1 proviruses in circulating CD4(+) T cells and rebound viruses emerging during treatment interruption
por: Lu, Ching-Lan, et al.
Publicado: (2018)

Distinct gene expression by expanded clones of quiescent memory CD4(+) T cells harboring intact latent HIV-1 proviruses
por: Weymar, Georg H.J., et al.
Publicado: (2022)

Intact provirus and integration sites analysis in acute HIV-1 infection and changes after one year of early antiviral therapy
por: Rozera, Gabriella, et al.
Publicado: (2022)

Impact of misclassified defective proviruses on HIV reservoir measurements
por: Reeves, Daniel B., et al.
Publicado: (2023)

Paucity of Intact Non-Induced Provirus with Early, Long-Term Antiretroviral Therapy of Perinatal HIV Infection
por: Rainwater-Lovett, Kaitlin, et al.
Publicado: (2017)

Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
por: Hiener, Bonnie, et al.
Publicado: (2018)

Characterization of Intact Proviruses in Blood and Lymph Node from HIV-Infected Individuals Undergoing Analytical Treatment Interruption
por: Vibholm, Line K., et al.
Publicado: (2019)

Adaptation of the intact proviral DNA assay to a nanowell-based digital PCR platform
por: Tumpach, Carolin, et al.
Publicado: (2023)

Defective HIV-1 proviruses produce viral proteins
por: Imamichi, Hiromi, et al.
Publicado: (2020)

HIV-1 Genomes Are Enriched in Memory CD4(+) T-Cells with Short Half-Lives
por: Morcilla, Vincent, et al.
Publicado: (2021)

A novel quantitative approach for measuring the reservoir of latent HIV-1 proviruses
por: Bruner, Katherine M., et al.
Publicado: (2019)

Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapy
por: White, Jennifer A., et al.
Publicado: (2022)

Transcriptional and Epigenetic Regulatory Mechanisms Affecting HTLV-1 Provirus
por: Miyazato, Paola, et al.
Publicado: (2016)

Activation of HIV-1 proviruses increases downstream chromatin accessibility
por: Shah, Raven, et al.
Publicado: (2022)

Targeting Immune Checkpoint Molecules to Eliminate Latent HIV
por: Boyer, Zoe, et al.
Publicado: (2018)

Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators
por: Le Mercier, Isabelle, et al.
Publicado: (2015)

Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4
por: Qin, Shuang, et al.
Publicado: (2019)

Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer
por: Zhang, Hao, et al.
Publicado: (2021)

Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1
por: Tyagi, Mudit, et al.
Publicado: (2015)

Chromatin control of Tat-mediated reactivation of latent HIV-1 provirus
por: Masse, Guillemette X, et al.
Publicado: (2009)

Intragenic proviral elements support transcription of defective HIV-1 proviruses
por: Kuniholm, Jeffrey, et al.
Publicado: (2021)

Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses
por: Einkauf, Kevin B., et al.
Publicado: (2022)

CTLA4 as Immunological Checkpoint in the Development of Multiple Sclerosis
por: Gerdes, Lisa Ann, et al.
Publicado: (2016)

HIV-1 gene expression: lessons from provirus and non-integrated DNA
por: Wu, Yuntao
Publicado: (2004)

Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus
por: Ebina, Hirotaka, et al.
Publicado: (2013)

CRISPR/Cas9 Genome Editing to Disable the Latent HIV-1 Provirus
por: Panfil, Amanda R., et al.
Publicado: (2018)

The chromatin landscape at the HIV-1 provirus integration site determines viral expression
por: Vansant, Gerlinde, et al.
Publicado: (2020)

Chromatin maturation of the HIV-1 provirus in primary resting CD4(+) T cells
por: Lindqvist, Birgitta, et al.
Publicado: (2020)

The Novel Halovirus Hardycor1, and the Presence of Active (Induced) Proviruses in Four Haloarchaea
por: Dyall-Smith, Mike, et al.
Publicado: (2021)

Towards a Functional Cure of HIV-1: Insight Into the Chromatin Landscape of the Provirus
por: Janssens, Julie, et al.
Publicado: (2021)

Insertional activation of STAT3 and LCK by HIV-1 proviruses in T cell lymphomas
por: Mellors, John W., et al.
Publicado: (2021)

Intranuclear Positions of HIV-1 Proviruses Are Dynamic and Do Not Correlate with Transcriptional Activity
por: Burdick, Ryan C., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_55483160os8qasvalm3o1lo4sn