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What Drives Chorismate Mutase to Top Performance? Insights from a Combined In Silico and In Vitro Study
[Image: see text] Unlike typical chorismate mutases, the enzyme from Mycobacterium tuberculosis (MtCM) has only low activity on its own. Remarkably, its catalytic efficiency k(cat)/K(m) can be boosted more than 100-fold by complex formation with a partner enzyme. Recently, an autonomously fully acti...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910054/ https://www.ncbi.nlm.nih.gov/pubmed/36705397 http://dx.doi.org/10.1021/acs.biochem.2c00635 |