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What Drives Chorismate Mutase to Top Performance? Insights from a Combined In Silico and In Vitro Study

[Image: see text] Unlike typical chorismate mutases, the enzyme from Mycobacterium tuberculosis (MtCM) has only low activity on its own. Remarkably, its catalytic efficiency k(cat)/K(m) can be boosted more than 100-fold by complex formation with a partner enzyme. Recently, an autonomously fully acti...

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Detalles Bibliográficos
Autores principales:	Thorbjørnsrud, Helen V., Bressan, Luca, Khatanbaatar, Tamjidmaa, Carrer, Manuel, Würth-Roderer, Kathrin, Cordara, Gabriele, Kast, Peter, Cascella, Michele, Krengel, Ute
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910054/ https://www.ncbi.nlm.nih.gov/pubmed/36705397 http://dx.doi.org/10.1021/acs.biochem.2c00635

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