Peroxide-cleavable linkers for antibody–drug conjugates

Antibody–drug conjugates containing peroxide-cleavable arylboronic acid linkers are described, which target the high levels of reactive oxygen species (ROS) in cancer. The arylboronic acid linkers rapidly release a payload in the presence of hydrogen peroxide, but remain stable in plasma. Anti-HER2...

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Detalles Bibliográficos
Autores principales: Ashman, Nicola, Bargh, Jonathan D., Walsh, Stephen J., Greenwood, Ryan D., Tiberghien, Arnaud, Carroll, Jason S., Spring, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910056/
https://www.ncbi.nlm.nih.gov/pubmed/36722863
http://dx.doi.org/10.1039/d2cc06677g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910056/
https://www.ncbi.nlm.nih.gov/pubmed/36722863
http://dx.doi.org/10.1039/d2cc06677g

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