Peroxide-cleavable linkers for antibody–drug conjugates

Antibody–drug conjugates containing peroxide-cleavable arylboronic acid linkers are described, which target the high levels of reactive oxygen species (ROS) in cancer. The arylboronic acid linkers rapidly release a payload in the presence of hydrogen peroxide, but remain stable in plasma. Anti-HER2...

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Detalles Bibliográficos
Autores principales: Ashman, Nicola, Bargh, Jonathan D., Walsh, Stephen J., Greenwood, Ryan D., Tiberghien, Arnaud, Carroll, Jason S., Spring, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910056/
https://www.ncbi.nlm.nih.gov/pubmed/36722863
http://dx.doi.org/10.1039/d2cc06677g
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author Ashman, Nicola
Bargh, Jonathan D.
Walsh, Stephen J.
Greenwood, Ryan D.
Tiberghien, Arnaud
Carroll, Jason S.
Spring, David R.
author_facet Ashman, Nicola
Bargh, Jonathan D.
Walsh, Stephen J.
Greenwood, Ryan D.
Tiberghien, Arnaud
Carroll, Jason S.
Spring, David R.
author_sort Ashman, Nicola
collection PubMed
description Antibody–drug conjugates containing peroxide-cleavable arylboronic acid linkers are described, which target the high levels of reactive oxygen species (ROS) in cancer. The arylboronic acid linkers rapidly release a payload in the presence of hydrogen peroxide, but remain stable in plasma. Anti-HER2 and PD-L1 peroxide-cleavable ADCs exhibited potent cytotoxicity in vitro.
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spelling pubmed-99100562023-02-10 Peroxide-cleavable linkers for antibody–drug conjugates Ashman, Nicola Bargh, Jonathan D. Walsh, Stephen J. Greenwood, Ryan D. Tiberghien, Arnaud Carroll, Jason S. Spring, David R. Chem Commun (Camb) Chemistry Antibody–drug conjugates containing peroxide-cleavable arylboronic acid linkers are described, which target the high levels of reactive oxygen species (ROS) in cancer. The arylboronic acid linkers rapidly release a payload in the presence of hydrogen peroxide, but remain stable in plasma. Anti-HER2 and PD-L1 peroxide-cleavable ADCs exhibited potent cytotoxicity in vitro. The Royal Society of Chemistry 2023-01-18 /pmc/articles/PMC9910056/ /pubmed/36722863 http://dx.doi.org/10.1039/d2cc06677g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Ashman, Nicola
Bargh, Jonathan D.
Walsh, Stephen J.
Greenwood, Ryan D.
Tiberghien, Arnaud
Carroll, Jason S.
Spring, David R.
Peroxide-cleavable linkers for antibody–drug conjugates
title Peroxide-cleavable linkers for antibody–drug conjugates
title_full Peroxide-cleavable linkers for antibody–drug conjugates
title_fullStr Peroxide-cleavable linkers for antibody–drug conjugates
title_full_unstemmed Peroxide-cleavable linkers for antibody–drug conjugates
title_short Peroxide-cleavable linkers for antibody–drug conjugates
title_sort peroxide-cleavable linkers for antibody–drug conjugates
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910056/
https://www.ncbi.nlm.nih.gov/pubmed/36722863
http://dx.doi.org/10.1039/d2cc06677g
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