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Peroxide-cleavable linkers for antibody–drug conjugates

Antibody–drug conjugates containing peroxide-cleavable arylboronic acid linkers are described, which target the high levels of reactive oxygen species (ROS) in cancer. The arylboronic acid linkers rapidly release a payload in the presence of hydrogen peroxide, but remain stable in plasma. Anti-HER2...

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Detalles Bibliográficos
Autores principales:	Ashman, Nicola, Bargh, Jonathan D., Walsh, Stephen J., Greenwood, Ryan D., Tiberghien, Arnaud, Carroll, Jason S., Spring, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910056/ https://www.ncbi.nlm.nih.gov/pubmed/36722863 http://dx.doi.org/10.1039/d2cc06677g

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