Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis

[Image: see text] Herein, we report dipropylamine (DPA) as a fluorenylmethyloxycarbonyl (Fmoc) deprotection reagent to strongly reduce aspartimide formation compared to piperidine (PPR) in high-temperature (60 °C) solid-phase peptide synthesis (SPPS). In contrast to PPR, DPA is readily available, in...

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Detalles Bibliográficos
Autores principales: Personne, Hippolyte, Siriwardena, Thissa N., Javor, Sacha, Reymond, Jean-Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910063/
https://www.ncbi.nlm.nih.gov/pubmed/36777595
http://dx.doi.org/10.1021/acsomega.2c07861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910063/
https://www.ncbi.nlm.nih.gov/pubmed/36777595
http://dx.doi.org/10.1021/acsomega.2c07861

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