Cargando…

Progranulin deficiency suppresses allergic asthma and enhances efferocytosis via PPAR‐γ/MFG‐E8 regulation in macrophages

Efferocytosis can resolve airway inflammation and enhance airway tolerance in allergic asthma. While previous work has reported that progranulin (PGRN) regulated macrophage efferocytosis, but it is unclear whether PGRN‐mediated efferocytosis is associated with asthma. Here, we found that in an ovalb...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Qi, Weng, Danlin, Yao, Shifei, Shen, Hailan, Gao, Song, Zhang, Yanyu, Huang, Wenjie, Wang, Yan, Wang, Hong, Xu, Wenchun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910167/ https://www.ncbi.nlm.nih.gov/pubmed/36840485 http://dx.doi.org/10.1002/iid3.779

Ejemplares similares

IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4(+)T cells
por: Zhang, Yanyu, et al.
Publicado: (2023)

Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice
por: Tee, Jong Huat, et al.
Publicado: (2023)

MFG-E8 promotes tendon-bone healing by regualting macrophage efferocytosis and M2 polarization after anterior cruciate ligament reconstruction
por: Geng, Rui, et al.
Publicado: (2022)

Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages
por: Mota, Ana Carolina, et al.
Publicado: (2021)

The Role of PPAR-γ in Allergic Disease
por: Stark, Julian M., et al.
Publicado: (2021)

Modulation of Macrophage Efferocytosis in Inflammation
por: Korns, Darlynn, et al.
Publicado: (2011)

Efferocytosis is impaired in Gaucher macrophages
por: Aflaki, Elma, et al.
Publicado: (2017)

Galectin-3 enhances monocyte-derived macrophage efferocytosis of apoptotic granulocytes in asthma
por: Erriah, Melanie, et al.
Publicado: (2019)

Contribution of Macrophage Efferocytosis to Liver Homeostasis and Disease
por: Horst, Andrea Kristina, et al.
Publicado: (2019)

Phagocytosis and Efferocytosis by Resident Macrophages in the Mouse Pancreas
por: Parv, Kristel, et al.
Publicado: (2021)

PPARγ activation following apoptotic cell instillation promotes resolution of lung inflammation and fibrosis via regulation of efferocytosis and proresolving cytokines
por: Yoon, Y-S, et al.
Publicado: (2015)

DEL-1 promotes macrophage efferocytosis and clearance of inflammation
por: Kourtzelis, Ioannis, et al.
Publicado: (2018)

Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation
por: Felton, Jennifer M., et al.
Publicado: (2018)

Redox Regulation of PPARγ in Polarized Macrophages
por: Trümper, Verena, et al.
Publicado: (2020)

MFG on track with Georgia plant upgrades
Publicado: (2020)

Zinc and Zinc Transporters in Macrophages and Their Roles in Efferocytosis in COPD
por: Hamon, Rhys, et al.
Publicado: (2014)

Efferocytosis perpetuates substance accumulation inside macrophage populations
por: Ford, Hugh Z., et al.
Publicado: (2019)

Macrophage efferocytosis with VEGFC and lymphangiogenesis: rescuing the broken heart
por: D’Amore, Patricia A., et al.
Publicado: (2022)

Inhibiting efferocytosis reverses macrophage-mediated immunosuppression in the leukemia microenvironment
por: Cruz Cruz, Joselyn, et al.
Publicado: (2023)

MFG-E8 has guiding significance for the prognosis and treatment of sepsis
por: Wu, Wei, et al.
Publicado: (2022)

Neurogenesis in Neurodegenerative Diseases: Role of MFG-E8
por: Cheyuo, Cletus, et al.
Publicado: (2019)

A glimpse of the connection between PPARγ and macrophage
por: Yu, Lexiang, et al.
Publicado: (2023)

Efferocytosis and Respiratory Disease
por: Zheng, Wenxue, et al.
Publicado: (2023)

Efferocytosis in multisystem diseases
por: Zhang, Yifan, et al.
Publicado: (2022)

Tanshinone IIA alleviates atherosclerosis in LDLR(−/−) mice by regulating efferocytosis of macrophages
por: Wang, Jiarou, et al.
Publicado: (2023)

MFG-E8 Released by Apoptotic Endothelial Cells Triggers Anti-Inflammatory Macrophage Reprogramming
por: Brissette, Marie-Joëlle, et al.
Publicado: (2012)

Emerging Functions of ICAM-1 in Macrophage Efferocytosis and Wound Healing
por: Dalal, Prarthana J., et al.
Publicado: (2020)

Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages
por: Zarrow, Jonah E., et al.
Publicado: (2023)

Mechanisms of continual efferocytosis by macrophages and its role in mitigating atherosclerosis
por: Kumar, Dhananjay, et al.
Publicado: (2023)

Efferocytosis and Its Role in Inflammatory Disorders
por: Ge, Yun, et al.
Publicado: (2022)

PPARγ Expression Is Diminished in Macrophages of Recurrent Miscarriage Placentas
por: Kolben, Theresa Maria, et al.
Publicado: (2018)

Role of clusterin/progranulin in toluene diisocyanate-induced occupational asthma
por: Choi, Gil-Soon, et al.
Publicado: (2018)

The role of progranulin (PGRN) in the modulation of anti-inflammatory response in asthma
por: Pogonowska, Milena, et al.
Publicado: (2019)

Ferroptotic MSCs protect mice against sepsis via promoting macrophage efferocytosis
por: Pan, Yuchen, et al.
Publicado: (2022)

Efferocytosis in the Central Nervous System
por: Zhao, Jiayi, et al.
Publicado: (2021)

COPD exacerbation severity and frequency is associated with impaired macrophage efferocytosis of eosinophils
por: Eltboli, Osama, et al.
Publicado: (2014)

Pulsed Electromagnetic Field Inhibits Synovitis via Enhancing the Efferocytosis of Macrophages
por: Ouyang, Junjie, et al.
Publicado: (2020)

Macrophage-produced VEGFC is induced by efferocytosis to ameliorate cardiac injury and inflammation
por: Glinton, Kristofor E., et al.
Publicado: (2022)

Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis
por: Mahida, Rahul Y., et al.
Publicado: (2021)

Efferocytosis in the tumor microenvironment
por: Werfel, Thomas A., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ptl73kq6m16r23rooi2gitatb3