Knockout of ACE-N facilitates improved cardiac function after myocardial infarction

Angiotensin-converting enzyme (ACE) hydrolyzes N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) into inactive fragments through its N-terminal site (ACE—N). We previously showed that Ac-SDKP mediates ACE inhibitors’ cardiac effects. Whether increased bioavailability of endogenous Ac-SDKP caused by kn...

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Detalles Bibliográficos
Autores principales: Suhail, Hamid, Peng, Hongmei, Xu, Jiang, Sabbah, Hani N., Matrougui, Khalid, Liao, Tang-Dong, Ortiz, Pablo A., Bernstein, Kenneth E., Rhaleb, Nour-Eddine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910327/
https://www.ncbi.nlm.nih.gov/pubmed/36778784
http://dx.doi.org/10.1016/j.jmccpl.2022.100024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910327/
https://www.ncbi.nlm.nih.gov/pubmed/36778784
http://dx.doi.org/10.1016/j.jmccpl.2022.100024

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