Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity

The drug praziquantel (PZQ) is the key clinical therapy for treating schistosomiasis and other infections caused by parasitic flatworms. A schistosome target for PZQ was recently identified— a transient receptor potential ion channel in the melastatin subfamily (TRPM(PZQ))—however, little is known a...

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Detalles Bibliográficos
Autores principales: Rohr, Claudia M., Sprague, Daniel J., Park, Sang-Kyu, Malcolm, Nicholas J., Marchant, Jonathan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910428/
https://www.ncbi.nlm.nih.gov/pubmed/36574686
http://dx.doi.org/10.1073/pnas.2217732120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910428/
https://www.ncbi.nlm.nih.gov/pubmed/36574686
http://dx.doi.org/10.1073/pnas.2217732120

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