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Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice
γδ T cells are involved in the control of Staphylococcus aureus infection, but their importance in protection compared to other T cells is unclear. We used a mouse model of systemic S. aureus infection associated with high bacterial load and persistence in the kidney. Infection caused fulminant accu...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910431/ https://www.ncbi.nlm.nih.gov/pubmed/36574651 http://dx.doi.org/10.1073/pnas.2210490120 |
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author | Bertram, Tabea Reimers, Daniel Lory, Niels C. Schmidt, Constantin Schmid, Joanna C. Heinig, Lisa Bradtke, Peter Rattay, Guido Zielinski, Stephanie Hellmig, Malte Bartsch, Patricia Rohde, Holger Nuñez, Sarah Rosemblatt, Mariana V. Bono, Maria Rosa Gagliani, Nicola Sandrock, Inga Panzer, Ulf Krebs, Christian F. Meyer-Schwesinger, Catherine Prinz, Immo Mittrücker, Hans-Willi |
author_facet | Bertram, Tabea Reimers, Daniel Lory, Niels C. Schmidt, Constantin Schmid, Joanna C. Heinig, Lisa Bradtke, Peter Rattay, Guido Zielinski, Stephanie Hellmig, Malte Bartsch, Patricia Rohde, Holger Nuñez, Sarah Rosemblatt, Mariana V. Bono, Maria Rosa Gagliani, Nicola Sandrock, Inga Panzer, Ulf Krebs, Christian F. Meyer-Schwesinger, Catherine Prinz, Immo Mittrücker, Hans-Willi |
author_sort | Bertram, Tabea |
collection | PubMed |
description | γδ T cells are involved in the control of Staphylococcus aureus infection, but their importance in protection compared to other T cells is unclear. We used a mouse model of systemic S. aureus infection associated with high bacterial load and persistence in the kidney. Infection caused fulminant accumulation of γδ T cells in the kidney. Renal γδ T cells acquired tissue residency and were maintained in high numbers during chronic infection. At day 7, up to 50% of renal γδ T cells produced IL-17A in situ and a large fraction of renal γδ T cells remained IL-17A(+) during chronic infection. Controlled depletion revealed that γδ T cells restricted renal S. aureus replication in the acute infection and provided protection during chronic renal infection and upon reinfection. Our results demonstrate that kidney-resident γδ T cells are nonredundant in limiting local S. aureus growth during chronic infection and provide enhanced protection against reinfection. |
format | Online Article Text |
id | pubmed-9910431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-99104312023-06-27 Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice Bertram, Tabea Reimers, Daniel Lory, Niels C. Schmidt, Constantin Schmid, Joanna C. Heinig, Lisa Bradtke, Peter Rattay, Guido Zielinski, Stephanie Hellmig, Malte Bartsch, Patricia Rohde, Holger Nuñez, Sarah Rosemblatt, Mariana V. Bono, Maria Rosa Gagliani, Nicola Sandrock, Inga Panzer, Ulf Krebs, Christian F. Meyer-Schwesinger, Catherine Prinz, Immo Mittrücker, Hans-Willi Proc Natl Acad Sci U S A Biological Sciences γδ T cells are involved in the control of Staphylococcus aureus infection, but their importance in protection compared to other T cells is unclear. We used a mouse model of systemic S. aureus infection associated with high bacterial load and persistence in the kidney. Infection caused fulminant accumulation of γδ T cells in the kidney. Renal γδ T cells acquired tissue residency and were maintained in high numbers during chronic infection. At day 7, up to 50% of renal γδ T cells produced IL-17A in situ and a large fraction of renal γδ T cells remained IL-17A(+) during chronic infection. Controlled depletion revealed that γδ T cells restricted renal S. aureus replication in the acute infection and provided protection during chronic renal infection and upon reinfection. Our results demonstrate that kidney-resident γδ T cells are nonredundant in limiting local S. aureus growth during chronic infection and provide enhanced protection against reinfection. National Academy of Sciences 2022-12-27 2023-01-03 /pmc/articles/PMC9910431/ /pubmed/36574651 http://dx.doi.org/10.1073/pnas.2210490120 Text en Copyright © 2022 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Biological Sciences Bertram, Tabea Reimers, Daniel Lory, Niels C. Schmidt, Constantin Schmid, Joanna C. Heinig, Lisa Bradtke, Peter Rattay, Guido Zielinski, Stephanie Hellmig, Malte Bartsch, Patricia Rohde, Holger Nuñez, Sarah Rosemblatt, Mariana V. Bono, Maria Rosa Gagliani, Nicola Sandrock, Inga Panzer, Ulf Krebs, Christian F. Meyer-Schwesinger, Catherine Prinz, Immo Mittrücker, Hans-Willi Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice |
title | Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice |
title_full | Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice |
title_fullStr | Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice |
title_full_unstemmed | Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice |
title_short | Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice |
title_sort | kidney-resident innate-like memory γδ t cells control chronic staphylococcus aureus infection of mice |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910431/ https://www.ncbi.nlm.nih.gov/pubmed/36574651 http://dx.doi.org/10.1073/pnas.2210490120 |
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