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Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice

γδ T cells are involved in the control of Staphylococcus aureus infection, but their importance in protection compared to other T cells is unclear. We used a mouse model of systemic S. aureus infection associated with high bacterial load and persistence in the kidney. Infection caused fulminant accu...

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Autores principales: Bertram, Tabea, Reimers, Daniel, Lory, Niels C., Schmidt, Constantin, Schmid, Joanna, C. Heinig, Lisa, Bradtke, Peter, Rattay, Guido, Zielinski, Stephanie, Hellmig, Malte, Bartsch, Patricia, Rohde, Holger, Nuñez, Sarah, Rosemblatt, Mariana V., Bono, Maria Rosa, Gagliani, Nicola, Sandrock, Inga, Panzer, Ulf, Krebs, Christian F., Meyer-Schwesinger, Catherine, Prinz, Immo, Mittrücker, Hans-Willi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910431/
https://www.ncbi.nlm.nih.gov/pubmed/36574651
http://dx.doi.org/10.1073/pnas.2210490120
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author Bertram, Tabea
Reimers, Daniel
Lory, Niels C.
Schmidt, Constantin
Schmid, Joanna
C. Heinig, Lisa
Bradtke, Peter
Rattay, Guido
Zielinski, Stephanie
Hellmig, Malte
Bartsch, Patricia
Rohde, Holger
Nuñez, Sarah
Rosemblatt, Mariana V.
Bono, Maria Rosa
Gagliani, Nicola
Sandrock, Inga
Panzer, Ulf
Krebs, Christian F.
Meyer-Schwesinger, Catherine
Prinz, Immo
Mittrücker, Hans-Willi
author_facet Bertram, Tabea
Reimers, Daniel
Lory, Niels C.
Schmidt, Constantin
Schmid, Joanna
C. Heinig, Lisa
Bradtke, Peter
Rattay, Guido
Zielinski, Stephanie
Hellmig, Malte
Bartsch, Patricia
Rohde, Holger
Nuñez, Sarah
Rosemblatt, Mariana V.
Bono, Maria Rosa
Gagliani, Nicola
Sandrock, Inga
Panzer, Ulf
Krebs, Christian F.
Meyer-Schwesinger, Catherine
Prinz, Immo
Mittrücker, Hans-Willi
author_sort Bertram, Tabea
collection PubMed
description γδ T cells are involved in the control of Staphylococcus aureus infection, but their importance in protection compared to other T cells is unclear. We used a mouse model of systemic S. aureus infection associated with high bacterial load and persistence in the kidney. Infection caused fulminant accumulation of γδ T cells in the kidney. Renal γδ T cells acquired tissue residency and were maintained in high numbers during chronic infection. At day 7, up to 50% of renal γδ T cells produced IL-17A in situ and a large fraction of renal γδ T cells remained IL-17A(+) during chronic infection. Controlled depletion revealed that γδ T cells restricted renal S. aureus replication in the acute infection and provided protection during chronic renal infection and upon reinfection. Our results demonstrate that kidney-resident γδ T cells are nonredundant in limiting local S. aureus growth during chronic infection and provide enhanced protection against reinfection.
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spelling pubmed-99104312023-06-27 Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice Bertram, Tabea Reimers, Daniel Lory, Niels C. Schmidt, Constantin Schmid, Joanna C. Heinig, Lisa Bradtke, Peter Rattay, Guido Zielinski, Stephanie Hellmig, Malte Bartsch, Patricia Rohde, Holger Nuñez, Sarah Rosemblatt, Mariana V. Bono, Maria Rosa Gagliani, Nicola Sandrock, Inga Panzer, Ulf Krebs, Christian F. Meyer-Schwesinger, Catherine Prinz, Immo Mittrücker, Hans-Willi Proc Natl Acad Sci U S A Biological Sciences γδ T cells are involved in the control of Staphylococcus aureus infection, but their importance in protection compared to other T cells is unclear. We used a mouse model of systemic S. aureus infection associated with high bacterial load and persistence in the kidney. Infection caused fulminant accumulation of γδ T cells in the kidney. Renal γδ T cells acquired tissue residency and were maintained in high numbers during chronic infection. At day 7, up to 50% of renal γδ T cells produced IL-17A in situ and a large fraction of renal γδ T cells remained IL-17A(+) during chronic infection. Controlled depletion revealed that γδ T cells restricted renal S. aureus replication in the acute infection and provided protection during chronic renal infection and upon reinfection. Our results demonstrate that kidney-resident γδ T cells are nonredundant in limiting local S. aureus growth during chronic infection and provide enhanced protection against reinfection. National Academy of Sciences 2022-12-27 2023-01-03 /pmc/articles/PMC9910431/ /pubmed/36574651 http://dx.doi.org/10.1073/pnas.2210490120 Text en Copyright © 2022 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Bertram, Tabea
Reimers, Daniel
Lory, Niels C.
Schmidt, Constantin
Schmid, Joanna
C. Heinig, Lisa
Bradtke, Peter
Rattay, Guido
Zielinski, Stephanie
Hellmig, Malte
Bartsch, Patricia
Rohde, Holger
Nuñez, Sarah
Rosemblatt, Mariana V.
Bono, Maria Rosa
Gagliani, Nicola
Sandrock, Inga
Panzer, Ulf
Krebs, Christian F.
Meyer-Schwesinger, Catherine
Prinz, Immo
Mittrücker, Hans-Willi
Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice
title Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice
title_full Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice
title_fullStr Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice
title_full_unstemmed Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice
title_short Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice
title_sort kidney-resident innate-like memory γδ t cells control chronic staphylococcus aureus infection of mice
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910431/
https://www.ncbi.nlm.nih.gov/pubmed/36574651
http://dx.doi.org/10.1073/pnas.2210490120
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