Inhibiting androgen receptor splice variants with cysteine-selective irreversible covalent inhibitors to treat prostate cancer

Androgen receptor (AR) and its splice variants (AR-SVs) promote prostate cancer (PCa) growth by orchestrating transcriptional reprogramming. Mechanisms by which the low complexity and intrinsically disordered primary transactivation domain (AF-1) of AR and AR-SVs regulate transcriptional programming...

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Detalles Bibliográficos
Autores principales: Thiyagarajan, Thirumagal, Ponnusamy, Suriyan, Hwang, Dong-Jin, He, Yali, Asemota, Sarah, Young, Kirsten L., Johnson, Daniel L., Bocharova, Vera, Zhou, Weidong, Jain, Abhinav K., Petricoin, Emanuel F., Yin, Zheng, Pfeffer, Lawrence M., Miller, Duane D., Narayanan, Ramesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910435/
https://www.ncbi.nlm.nih.gov/pubmed/36577061
http://dx.doi.org/10.1073/pnas.2211832120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910435/
https://www.ncbi.nlm.nih.gov/pubmed/36577061
http://dx.doi.org/10.1073/pnas.2211832120

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