Unusual phototransduction via cross-motif signaling from G(q) to adenylyl cyclase in intrinsically photosensitive retinalganglion cells

Nonimage-forming vision in mammals is mediated primarily by melanopsin (OPN4)-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs). In mouse M1-ipRGCs, melanopsin predominantly activates, via Gα(q,11,14), phospholipase C-β4 to open transient receptor 6 (TRPC6) and TRPC7 channels....

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Detalles Bibliográficos
Autores principales: Chen, Lujing, Li, Guang, Jiang, Zheng, Yau, King-Wai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910442/
https://www.ncbi.nlm.nih.gov/pubmed/36584299
http://dx.doi.org/10.1073/pnas.2216599120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910442/
https://www.ncbi.nlm.nih.gov/pubmed/36584299
http://dx.doi.org/10.1073/pnas.2216599120

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