Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2

ABCG2 is an ATP-binding cassette (ABC) transporter that extrudes a wide range of xenobiotics and drugs from the cell and contributes to multidrug resistance in cancer cells. Following our recent structural characterization of topotecan-bound ABCG2, here, we present cryo-EM structures of ABCG2 under...

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Detalles Bibliográficos
Autores principales: Rasouli, Ali, Yu, Qin, Dehghani-Ghahnaviyeh, Sepehr, Wen, Po-Chao, Kowal, Julia, Locher, Kaspar P., Tajkhorshid, Emad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910490/
https://www.ncbi.nlm.nih.gov/pubmed/36580587
http://dx.doi.org/10.1073/pnas.2213437120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910490/
https://www.ncbi.nlm.nih.gov/pubmed/36580587
http://dx.doi.org/10.1073/pnas.2213437120

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