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Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2

ABCG2 is an ATP-binding cassette (ABC) transporter that extrudes a wide range of xenobiotics and drugs from the cell and contributes to multidrug resistance in cancer cells. Following our recent structural characterization of topotecan-bound ABCG2, here, we present cryo-EM structures of ABCG2 under...

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Detalles Bibliográficos
Autores principales:	Rasouli, Ali, Yu, Qin, Dehghani-Ghahnaviyeh, Sepehr, Wen, Po-Chao, Kowal, Julia, Locher, Kaspar P., Tajkhorshid, Emad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910490/ https://www.ncbi.nlm.nih.gov/pubmed/36580587 http://dx.doi.org/10.1073/pnas.2213437120

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