Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases

De novo viral RNA-dependent RNA polymerases (RdRPs) utilize their priming element (PE) to facilitate accurate initiation. Upon transition to elongation, the PE has to retreat from the active site to give room to the template–product RNA duplex. However, PE conformational change upon this transition...

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Detalles Bibliográficos
Autores principales: Wu, Jiqin, Wang, Xinyu, Liu, Qiaojie, Lu, Guoliang, Gong, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910504/
https://www.ncbi.nlm.nih.gov/pubmed/36577062
http://dx.doi.org/10.1073/pnas.2211425120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910504/
https://www.ncbi.nlm.nih.gov/pubmed/36577062
http://dx.doi.org/10.1073/pnas.2211425120

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