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Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases
De novo viral RNA-dependent RNA polymerases (RdRPs) utilize their priming element (PE) to facilitate accurate initiation. Upon transition to elongation, the PE has to retreat from the active site to give room to the template–product RNA duplex. However, PE conformational change upon this transition...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910504/ https://www.ncbi.nlm.nih.gov/pubmed/36577062 http://dx.doi.org/10.1073/pnas.2211425120 |