Cargando…

SARS-CoV-2 RNA-dependent RNA polymerase as a target for high-throughput drug screening

The ongoing COVID-19 pandemic caused by the SARS-CoV-2 has necessitated rapid development of drug screening tools. RNA-dependent RNA polymerase (RdRp) is a promising target due to its essential functions in replication and transcription of viral genome. To date, through minimal RNA synthesizing mach...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Jiahui, Chen, Zhiqiang, Han, Xue, Chen, Qiaoqiao, Wang, Yintao, Feng, Tingting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Future Medicine Ltd 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910510/ https://www.ncbi.nlm.nih.gov/pubmed/36794167 http://dx.doi.org/10.2217/fvl-2021-0335

Ejemplares similares

Targeting SARS-CoV-2 RNA-dependent RNA polymerase: An in silico drug repurposing for COVID-19
por: Baby, Krishnaprasad, et al.
Publicado: (2020)

SARS-CoV-2 RNA Dependent RNA polymerase (RdRp) – A drug repurposing study
por: Ahmad, Jamshaid, et al.
Publicado: (2020)

Identification of Potential Key Agents for Targeting RNA-Dependent RNA Polymerase of SARS-CoV-2 by Integrated Analysis and Virtual Drug Screening
por: Ao, Shuang, et al.
Publicado: (2020)

Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2
por: Aranda, Juan, et al.
Publicado: (2022)

Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase
por: Zandi, Keivan, et al.
Publicado: (2021)

Combining SARS-CoV-2 Proofreading Exonuclease and RNA-Dependent RNA Polymerase Inhibitors as a Strategy to Combat COVID-19: A High-Throughput in silico Screening
por: Khater, Shradha, et al.
Publicado: (2021)

Discovering new potential inhibitors to SARS-CoV-2 RNA dependent RNA polymerase (RdRp) using high throughput virtual screening and molecular dynamics simulations
por: Brunt, Dylan, et al.
Publicado: (2022)

In silico analysis of RNA-dependent RNA polymerase of the SARS-CoV-2 and therapeutic potential of existing antiviral drugs
por: Mondal, Sunil Kanti, et al.
Publicado: (2021)

Global Genomic Analysis of SARS-CoV-2 RNA Dependent RNA Polymerase Evolution and Antiviral Drug Resistance
por: Mari, Alfredo, et al.
Publicado: (2021)

Repurposing of potential antiviral drugs against RNA-dependent RNA polymerase of SARS-CoV-2 by computational approach
por: Gangadharan, Sivakumar, et al.
Publicado: (2022)

Potential RNA-dependent RNA polymerase (RdRp) inhibitors as prospective drug candidates for SARS-CoV-2
por: Bekheit, Mohamed S., et al.
Publicado: (2023)

Identification of FDA-approved drugs against SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) through computational virtual screening
por: Jade, Dhananjay, et al.
Publicado: (2022)

Screening of potent drug inhibitors against SARS-CoV-2 RNA polymerase: an in silico approach
por: Singh, Sanjay Kumar, et al.
Publicado: (2021)

Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase
por: Li, Quanjie, et al.
Publicado: (2021)

Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP
por: Naydenova, Katerina, et al.
Publicado: (2021)

Inhibition of the RNA-dependent RNA Polymerase of the SARS-CoV-2 by Short Peptide Inhibitors
por: Pant, Suyash, et al.
Publicado: (2021)

Single molecule activity assay for SARS-CoV-2 RNA dependent RNA polymerase
por: Chung, SangYoon, et al.
Publicado: (2022)

Electron Density Analysis of SARS-CoV-2 RNA-Dependent RNA Polymerase Complexes
por: Palko, Nadezhda, et al.
Publicado: (2021)

Dynamic properties of SARS-CoV and SARS-CoV-2 RNA-dependent RNA polymerases studied by molecular dynamics simulations
por: Itoh, Satoru G., et al.
Publicado: (2021)

SARS-CoV-2 spike protein and RNA dependent RNA polymerase as targets for drug and vaccine development: A review
por: Muhammed, Yusuf, et al.
Publicado: (2021)

Seeking antiviral drugs to inhibit SARS-CoV-2 RNA dependent RNA polymerase: A molecular docking analysis
por: Khater, Ibrahim, et al.
Publicado: (2022)

A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase
por: Zhao, Jianyuan, et al.
Publicado: (2021)

Pharmacophore screening to identify natural origin compounds to target RNA-dependent RNA polymerase (RdRp) of SARS-CoV2
por: Mishra, Avinash, et al.
Publicado: (2022)

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
por: Yin, Wanchao, et al.
Publicado: (2020)

Potential RNA-dependent RNA polymerase inhibitors as prospective therapeutics against SARS-CoV-2
por: Pokhrel, Rudramani, et al.
Publicado: (2020)

The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2
por: Jin, Zhenming, et al.
Publicado: (2021)

A review on the interaction of nucleoside analogues with SARS-CoV-2 RNA dependent RNA polymerase
por: Khan, Suliman, et al.
Publicado: (2021)

Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication
por: Dejmek, Milan, et al.
Publicado: (2021)

Immunoinformatics Identification of B- and T-Cell Epitopes in the RNA-Dependent RNA Polymerase of SARS-CoV-2
por: Yashvardhini, Niti, et al.
Publicado: (2021)

Bioactive Molecules of Tea as Potential Inhibitors for RNA-Dependent RNA Polymerase of SARS-CoV-2
por: Bhardwaj, Vijay Kumar, et al.
Publicado: (2021)

“Bucket brigade” using lysine residues in RNA-dependent RNA polymerase of SARS-CoV-2
por: Tanimoto, Shoichi, et al.
Publicado: (2021)

Computational Study of SARS-CoV-2 RNA Dependent RNA Polymerase Allosteric Site Inhibition
por: Faisal, Shah, et al.
Publicado: (2021)

Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets
por: Maio, Nunziata, et al.
Publicado: (2021)

Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)
por: Wu, Yifei, et al.
Publicado: (2021)

In silico evaluation of potential intervention against SARS-CoV-2 RNA-dependent RNA polymerase
por: Kapoor, Shreya, et al.
Publicado: (2023)

Current understanding of nucleoside analogs inhibiting the SARS-CoV-2 RNA-dependent RNA polymerase
por: Xu, Tiantian, et al.
Publicado: (2023)

In silico studies of selected multi-drug targeting against 3CLpro and nsp12 RNA-dependent RNA-polymerase proteins of SARS-CoV-2 and SARS-CoV
por: Udofia, Inemesit A., et al.
Publicado: (2021)

Screening of SARS-CoV-2 antivirals through a cell-based RNA-dependent RNA polymerase (RdRp) reporter assay
por: Uppal, Timsy, et al.
Publicado: (2022)

Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs
por: Neogi, Ujjwal, et al.
Publicado: (2020)

Modeling the Binding Mechanism of Remdesivir, Favilavir, and Ribavirin to SARS-CoV-2 RNA-Dependent RNA Polymerase
por: Byléhn, Fabian, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_73sbbuf0optj1qj0tqh0e7ac72