Increased Physiological GDNF Levels Have No Effect on Dopamine Neuron Protection and Restoration in a Proteasome Inhibition Mouse Model of Parkinson’s Disease

Parkinson’s disease (PD) is a progressive neurodegenerative disease that comprises a range of motor and nonmotor symptoms. Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of dopamine neurons in vitro and in vivo, and intracranial delivery of GDNF has been tested in six clini...

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Detalles Bibliográficos
Autores principales: Olfat, Soophie, Mätlik, Kärt, Kopra, Jaakko J., Garton, Daniel R., Iivanainen, Vilma H., Bhattacharya, Dipabarna, Jakobsson, Johan, Piepponen, T. Petteri, Andressoo, Jaan-Olle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2023
Materias:
Research Article: Negative Results
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910577/
https://www.ncbi.nlm.nih.gov/pubmed/36690469
http://dx.doi.org/10.1523/ENEURO.0097-22.2023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910577/
https://www.ncbi.nlm.nih.gov/pubmed/36690469
http://dx.doi.org/10.1523/ENEURO.0097-22.2023

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