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Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein
The cellular prion protein (PrP(C)) converts to alternatively folded pathogenic conformations (PrP(Sc)) in prion infections and binds neurotoxic oligomers formed by amyloid-β α-synuclein, and tau. β-Endoproteolysis, which splits PrP(C) into N- and C-terminal fragments (N2 and C2, respectively), is o...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910601/ https://www.ncbi.nlm.nih.gov/pubmed/36574660 http://dx.doi.org/10.1073/pnas.2209815120 |