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Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein

The cellular prion protein (PrP(C)) converts to alternatively folded pathogenic conformations (PrP(Sc)) in prion infections and binds neurotoxic oligomers formed by amyloid-β α-synuclein, and tau. β-Endoproteolysis, which splits PrP(C) into N- and C-terminal fragments (N2 and C2, respectively), is o...

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Detalles Bibliográficos
Autores principales:	Castle, Andrew R., Kang, Sang-Gyun, Eskandari-Sedighi, Ghazaleh, Wohlgemuth, Serene, Nguyen, My-Anh, Drucker, Daniel J., Mulvihill, Erin E., Westaway, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910601/ https://www.ncbi.nlm.nih.gov/pubmed/36574660 http://dx.doi.org/10.1073/pnas.2209815120

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