Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis

Obesity is a major risk factor for cancer. Conventional thought suggests that elevated adiposity predisposes to heightened inflammatory stress and potentiates tumor growth, yet underlying mechanisms remain ill-defined. Here, we show that tumors from patients with a body mass index >35 carry a hig...

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Detalles Bibliográficos
Autores principales: Fournier, Frédérik, Diaz-Marin, Roberto, Pilon, Frédérique, Neault, Mathieu, Juneau, Rachel, Girouard, Gabrielle, Wilson, Ariel M., Larrivée, Bruno, Mallette, Frédérick A., Crespo-Garcia, Sergio, Sapieha, Przemyslaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910606/
https://www.ncbi.nlm.nih.gov/pubmed/36574648
http://dx.doi.org/10.1073/pnas.2209973120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910606/
https://www.ncbi.nlm.nih.gov/pubmed/36574648
http://dx.doi.org/10.1073/pnas.2209973120

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