Inhibition of GPR39 restores defects in endothelial cell–mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis

Impaired endothelial cell (EC)–mediated angiogenesis contributes to critical limb ischemia in diabetic patients. The sonic hedgehog (SHH) pathway participates in angiogenesis but is repressed in hyperglycemia by obscure mechanisms. We investigated the orphan G protein–coupled receptor GPR39 on SHH p...

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Detalles Bibliográficos
Autores principales: Meda Venkata, Sai Pranathi, Li, Hainan, Xu, Liping, Koh, Jia Yi, Nguyen, Huong, Minjares, Morgan, Li, Chunying, Kowluru, Anjaneyulu, Milligan, Graeme, Wang, Jie-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910611/
https://www.ncbi.nlm.nih.gov/pubmed/36574661
http://dx.doi.org/10.1073/pnas.2208541120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910611/
https://www.ncbi.nlm.nih.gov/pubmed/36574661
http://dx.doi.org/10.1073/pnas.2208541120

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