Cargando…
Inhibition of GPR39 restores defects in endothelial cell–mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis
Impaired endothelial cell (EC)–mediated angiogenesis contributes to critical limb ischemia in diabetic patients. The sonic hedgehog (SHH) pathway participates in angiogenesis but is repressed in hyperglycemia by obscure mechanisms. We investigated the orphan G protein–coupled receptor GPR39 on SHH p...
Autores principales: | Meda Venkata, Sai Pranathi, Li, Hainan, Xu, Liping, Koh, Jia Yi, Nguyen, Huong, Minjares, Morgan, Li, Chunying, Kowluru, Anjaneyulu, Milligan, Graeme, Wang, Jie-Mei |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910611/ https://www.ncbi.nlm.nih.gov/pubmed/36574661 http://dx.doi.org/10.1073/pnas.2208541120 |
Ejemplares similares
-
Novel Role of GPR35 (G-Protein–Coupled Receptor 35) in the Regulation of Endothelial Cell Function and Blood Pressure
por: Li, Hainan, et al.
Publicado: (2021) -
CARD9 Mediates Pancreatic Islet Beta-Cell Dysfunction Under the Duress of Hyperglycemic Stress
por: Gamage, Suhadinie, et al.
Publicado: (2022) -
MicroRNA-466 and microRNA-200 increase endothelial permeability in hyperglycemia by targeting Claudin-5
por: Kujawa, Marisa, et al.
Publicado: (2022) -
GPR39 deorphanization: The long and winding road to eicosanoids and a crosstalk between GPR39 and hedgehog signaling in angiogenesis
por: Doboszewska, Urszula, et al.
Publicado: (2023) -
Sonic hedgehog: its expression in a healing cornea and its role in neovascularization
por: Fujita, Kyoko, et al.
Publicado: (2009)