Differential requirement for BRCA1-BARD1 E3 ubiquitin ligase activity in DNA damage repair and meiosis in the Caenorhabditis elegans germ line

The tumor suppressor BRCA1-BARD1 complex regulates many cellular processes; of critical importance to its tumor suppressor function is its role in genome integrity. Although RING E3 ubiquitin ligase activity is the only known enzymatic activity of the complex, the in vivo requirement for BRCA1-BARD1...

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Detalles Bibliográficos
Autores principales: Li, Qianyan, Kaur, Arshdeep, Okada, Kyoko, McKenney, Richard J., Engebrecht, JoAnne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910797/
https://www.ncbi.nlm.nih.gov/pubmed/36716349
http://dx.doi.org/10.1371/journal.pgen.1010457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910797/
https://www.ncbi.nlm.nih.gov/pubmed/36716349
http://dx.doi.org/10.1371/journal.pgen.1010457

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