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De novo genes with an lncRNA origin encode unique human brain developmental functionality
Human de novo genes can originate from neutral long non-coding RNA (lncRNA) loci and are evolutionarily significant in general, yet how and why this all-or-nothing transition to functionality happens remains unclear. Here, in 74 human/hominoid-specific de novo genes, we identified distinctive U1 ele...
Autores principales: | An, Ni A., Zhang, Jie, Mo, Fan, Luan, Xuke, Tian, Lu, Shen, Qing Sunny, Li, Xiangshang, Li, Chunqiong, Zhou, Fanqi, Zhang, Boya, Ji, Mingjun, Qi, Jianhuan, Zhou, Wei-Zhen, Ding, Wanqiu, Chen, Jia-Yu, Yu, Jia, Zhang, Li, Shu, Shaokun, Hu, Baoyang, Li, Chuan-Yun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911349/ https://www.ncbi.nlm.nih.gov/pubmed/36593289 http://dx.doi.org/10.1038/s41559-022-01925-6 |
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