CD36 neutralisation blunts TLR2-IRF7 but not IRF3 pathway in neonatal mouse brain and immature human microglia following innate immune challenge

Innate immune response in neonatal brain is associated with a robust microglial activation and induction of Toll-like Receptors (TLRs). To date, the role of the scavenger receptor CD36 in TLRs modulation, particularly TLR2 signaling, has been well established in adult brain. However, the crosstalk b...

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Detalles Bibliográficos
Autores principales: Gadagkar, Shruti Gururaj, Lalancette-Hébert, Melanie, Thammisetty, Sai Sampath, Vexler, Zinaida S., Kriz, Jasna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911392/
https://www.ncbi.nlm.nih.gov/pubmed/36759676
http://dx.doi.org/10.1038/s41598-023-29423-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911392/
https://www.ncbi.nlm.nih.gov/pubmed/36759676
http://dx.doi.org/10.1038/s41598-023-29423-0

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