Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia

The PML::RARA fusion protein is the hallmark driver of Acute Promyelocytic Leukemia (APL) and disrupts retinoic acid signaling, leading to wide-scale gene expression changes and uncontrolled proliferation of myeloid precursor cells. While known to be recruited to binding sites across the genome, its...

Descripción completa

Detalles Bibliográficos
Autores principales: Villiers, William, Kelly, Audrey, He, Xiaohan, Kaufman-Cook, James, Elbasir, Abdurrahman, Bensmail, Halima, Lavender, Paul, Dillon, Richard, Mifsud, Borbála, Osborne, Cameron S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911410/
https://www.ncbi.nlm.nih.gov/pubmed/36759620
http://dx.doi.org/10.1038/s41467-023-36262-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911410/
https://www.ncbi.nlm.nih.gov/pubmed/36759620
http://dx.doi.org/10.1038/s41467-023-36262-0

Ejemplares similares