In-Silico Modelling of Transdermal Delivery of Macromolecule Drugs Assisted by a Skin Stretching Hypobaric Device

OBJECTIVES: To develop a simulation model to explore the interplay between mechanical stretch and diffusion of large molecules into the skin under locally applied hypobaric pressure, a novel penetration enhancement method. METHODS: Finite element method was used to model the skin mechanical deformat...

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Detalles Bibliográficos
Autores principales: Sebastia-Saez, Daniel, Benaouda, Faiza, Lim, Chui Hua, Lian, Guoping, Jones, Stuart A., Cui, Liang, Chen, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911480/
https://www.ncbi.nlm.nih.gov/pubmed/36348132
http://dx.doi.org/10.1007/s11095-022-03423-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911480/
https://www.ncbi.nlm.nih.gov/pubmed/36348132
http://dx.doi.org/10.1007/s11095-022-03423-7

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