Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

Ultra-long-acting delivery platforms for HIV pre-exposure prophylaxis (PrEP) may increase adherence and maximize public health benefit. We report on an injectable, biodegradable, and removable in-situ forming implant (ISFI) that is administered subcutaneously and can release the integrase inhibitor...

Descripción completa

Detalles Bibliográficos
Autores principales: Young, Isabella C., Massud, Ivana, Cottrell, Mackenzie L., Shrivastava, Roopali, Maturavongsadit, Panita, Prasher, Alka, Wong-Sam, Andres, Dinh, Chuong, Edwards, Tiancheng, Mrotz, Victoria, Mitchell, James, Seixas, Josilene Nascimento, Pallerla, Aryani, Thorson, Allison, Schauer, Amanda, Sykes, Craig, De la Cruz, Gabriela, Montgomery, Stephanie A., Kashuba, Angela D. M., Heneine, Walid, Dobard, Charles W., Kovarova, Martina, Garcia, J. Victor, Garcίa-Lerma, J. Gerardo, Benhabbour, S. Rahima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911691/
https://www.ncbi.nlm.nih.gov/pubmed/36759645
http://dx.doi.org/10.1038/s41467-023-36330-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911691/
https://www.ncbi.nlm.nih.gov/pubmed/36759645
http://dx.doi.org/10.1038/s41467-023-36330-5

Ejemplares similares