Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells

Oncogene activation creates DNA replication stress (RS) in cancer cells, which can generate under-replicated DNA regions (UDRs) that persist until cells enter mitosis. UDRs also have the potential to generate DNA bridges in anaphase cells or micronuclei in the daughter cells, which could promote gen...

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Detalles Bibliográficos
Autores principales: Wu, Wei, Barwacz, Szymon A., Bhowmick, Rahul, Lundgaard, Katrine, Gonçalves Dinis, Marisa M., Clausen, Malgorzata, Kanemaki, Masato T., Liu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911744/
https://www.ncbi.nlm.nih.gov/pubmed/36759509
http://dx.doi.org/10.1038/s41467-023-35992-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911744/
https://www.ncbi.nlm.nih.gov/pubmed/36759509
http://dx.doi.org/10.1038/s41467-023-35992-5

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