Cargando…

Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells

Oncogene activation creates DNA replication stress (RS) in cancer cells, which can generate under-replicated DNA regions (UDRs) that persist until cells enter mitosis. UDRs also have the potential to generate DNA bridges in anaphase cells or micronuclei in the daughter cells, which could promote gen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Wei, Barwacz, Szymon A., Bhowmick, Rahul, Lundgaard, Katrine, Gonçalves Dinis, Marisa M., Clausen, Malgorzata, Kanemaki, Masato T., Liu, Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911744/ https://www.ncbi.nlm.nih.gov/pubmed/36759509 http://dx.doi.org/10.1038/s41467-023-35992-5

Ejemplares similares

DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability
por: Ben Yamin, Barbara, et al.
Publicado: (2021)

Acute inactivation of the replicative helicase in human cells triggers MCM8–9-dependent DNA synthesis
por: Natsume, Toyoaki, et al.
Publicado: (2017)

TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication
por: Sonneville, Remi, et al.
Publicado: (2019)

Global landscape of replicative DNA polymerase usage in the human genome
por: Koyanagi, Eri, et al.
Publicado: (2022)

The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins
por: Zhong, Xuejun, et al.
Publicado: (2006)

DNA polymerase zeta is required for proliferation of normal mammalian cells
por: Lange, Sabine S., et al.
Publicado: (2012)

Overexpression of DNA Polymerase Zeta Reduces the Mitochondrial Mutability Caused by Pathological Mutations in DNA Polymerase Gamma in Yeast
por: Baruffini, Enrico, et al.
Publicado: (2012)

Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism
por: Özer, Özgün, et al.
Publicado: (2018)

The assembly of the MCM2–7 hetero-hexamer and its significance in DNA replication
por: Hatoyama, Yuki, et al.
Publicado: (2023)

Fe-S coordination defects in the replicative DNA polymerase delta cause deleterious DNA replication in vivo and subsequent DNA damage in the yeast Saccharomyces cerevisiae
por: Chanet, Roland, et al.
Publicado: (2021)

Human REV3 DNA Polymerase Zeta Localizes to Mitochondria and Protects the Mitochondrial Genome
por: Singh, Bhupendra, et al.
Publicado: (2015)

Replicative DNA polymerases
por: Albà, M Mar
Publicado: (2001)

The Major Roles of DNA Polymerases Epsilon and Delta at the Eukaryotic Replication Fork Are Evolutionarily Conserved
por: Miyabe, Izumi, et al.
Publicado: (2011)

DNA polymerase theta suppresses mitotic crossing over
por: Carvajal-Garcia, Juan, et al.
Publicado: (2021)

DNA polymerase ζ in DNA replication and repair
por: Martin, Sara K, et al.
Publicado: (2019)

DNA polymerase delta interacting protein 3 facilitates the activation and maintenance of DNA damage checkpoint in response to replication stress
por: Zhang, Sufang, et al.
Publicado: (2022)

Plant organellar DNA polymerases are replicative and translesion DNA synthesis polymerases
por: Baruch-Torres, Noe, et al.
Publicado: (2017)

Limiting DNA polymerase delta alters replication dynamics and leads to a dependence on checkpoint activation and recombination-mediated DNA repair
por: Koussa, Natasha C., et al.
Publicado: (2021)

Impact of the DNA polymerase Theta on the DNA replication program
por: Baldacci, Giuseppe, et al.
Publicado: (2014)

DNA Polymerase Gamma in Mitochondrial DNA Replication and Repair
por: Copeland, William C., et al.
Publicado: (2003)

DNA Helicase–Polymerase Coupling in Bacteriophage DNA Replication
por: Lo, Chen-Yu, et al.
Publicado: (2021)

Oxidative stress-induced mutagenesis in single-strand DNA occurs primarily at cytosines and is DNA polymerase zeta-dependent only for adenines and guanines
por: Degtyareva, Natalya P., et al.
Publicado: (2013)

Replicative DNA polymerase mutations in cancer()
por: Heitzer, Ellen, et al.
Publicado: (2014)

Characterization of thymus-derived lymphocytes expressing Ti alpha-beta CD3 gamma delta epsilon zeta-zeta, Ti alpha-beta CD3 gamma delta epsilon eta-eta or Ti alpha-beta CD3 gamma delta epsilon zeta-zeta/zeta- eta antigen receptor isoforms: analysis by gene transfection
Publicado: (1990)

Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations
por: Pavlov, Youri I, et al.
Publicado: (2004)

MCMBP promotes the assembly of the MCM2–7 hetero-hexamer to ensure robust DNA replication in human cells
por: Saito, Yuichiro, et al.
Publicado: (2022)

Structural basis of high fidelity DNA synthesis by yeast DNA polymerase delta
por: Swan, Michael K., et al.
Publicado: (2009)

P50, the Small Subunit of DNA Polymerase Delta, Is Required for Mediation of the Interaction of Polymerase Delta Subassemblies with PCNA
por: Wang, Yujue, et al.
Publicado: (2011)

Sequential assembly of translesion DNA polymerases at UV-induced DNA damage sites
por: Andersen, Parker L., et al.
Publicado: (2011)

DNA Polymerase-Parental DNA Interaction Is Essential for Helicase-Polymerase Coupling during Bacteriophage T7 DNA Replication
por: Lo, Chen-Yu, et al.
Publicado: (2022)

Correction: Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations
por: Pavlov, Youri I, et al.
Publicado: (2007)

Role of Translesion Synthesis DNA Polymerases in DNA Replication in the Presence of a Weak DNA Polymerase δ in Saccharomyces cerevisiae
por: Zhang, Likui, et al.
Publicado: (2018)

Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase
por: Morin, José A., et al.
Publicado: (2015)

Interference in DNA Replication Can Cause Mitotic Chromosomal Breakage Unassociated with Double-Strand Breaks
por: Fujita, Mari, et al.
Publicado: (2013)

DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D
por: Shah, Sandeep N., et al.
Publicado: (2010)

Evolution of replicative DNA polymerases in archaea and their contributions to the eukaryotic replication machinery
por: Makarova, Kira S., et al.
Publicado: (2014)

DNA moves sequentially towards the nuclear matrix during DNA replication in vivo
por: Rivera-Mulia, Juan Carlos, et al.
Publicado: (2011)

Human DNA polymerase delta requires an iron–sulfur cluster for high-fidelity DNA synthesis
por: Jozwiakowski, Stanislaw K., et al.
Publicado: (2019)

DNA Polymerase Delta Exhibits Altered Catalytic Properties on Lysine Acetylation
por: Njeri, Catherine, et al.
Publicado: (2023)

UBR5 interacts with the replication fork and protects DNA replication from DNA polymerase η toxicity
por: Cipolla, Lina, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_s98mp87pgdbj502iof5llr7i1g