Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT)

Telomere maintenance is necessary to maintain cancer cell unlimited viability. However, the mechanisms maintaining telomere length in colorectal cancer (CRC) have not been extensively investigated. Telomere maintenance mechanisms (TMM) include the re-expression of telomerase or alternative lengtheni...

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Detalles Bibliográficos
Autores principales: Falcinelli, Marta, Dell’Omo, Giulia, Grassi, Elena, Mariella, Elisa, Leto, Simonetta Maria, Scardellato, Sharon, Lorenzato, Annalisa, Arena, Sabrina, Bertotti, Andrea, Trusolino, Livio, Bardelli, Alberto, d’Adda di Fagagna, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911751/
https://www.ncbi.nlm.nih.gov/pubmed/36759506
http://dx.doi.org/10.1038/s41419-023-05640-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911751/
https://www.ncbi.nlm.nih.gov/pubmed/36759506
http://dx.doi.org/10.1038/s41419-023-05640-3

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