Elevated fatty acid β-oxidation by leptin contributes to the proinflammatory characteristics of fibroblast-like synoviocytes from RA patients via LKB1-AMPK pathway

Fibroblast-like synoviocytes (FLS) maintain chronic inflammation leading to joint destruction in rheumatoid arthritis (RA). Fatty acid β-oxidation (FAO) regulates cell function. Here, we aimed to investigate the effect of FAO enhanced by leptin on the characteristics of RA-FLS and elucidate the pote...

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Detalles Bibliográficos
Autores principales: Wei, Jing, Huang, Xinxin, Zhang, Xing, Chen, Guanghong, Zhang, Cheng, Zhou, Xinyang, Qi, Jingjing, Zhang, Yan, Li, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911755/
https://www.ncbi.nlm.nih.gov/pubmed/36759597
http://dx.doi.org/10.1038/s41419-023-05641-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911755/
https://www.ncbi.nlm.nih.gov/pubmed/36759597
http://dx.doi.org/10.1038/s41419-023-05641-2

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