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Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance
BRAF is prototypical of oncogenes that can be targeted therapeutically and the treatment of BRAF(V600E) melanomas with RAF and MEK inhibitors results in rapid tumor regression. However, drug‐induced rewiring generates a drug adapted state thought to be involved in acquired resistance and disease rec...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912026/ https://www.ncbi.nlm.nih.gov/pubmed/36700386 http://dx.doi.org/10.15252/msb.202210988 |