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Fully Automated Characterization of Protein–Peptide Binding by Microfluidic 2D NMR

[Image: see text] We demonstrate an automated microfluidic nuclear magnetic resonance (NMR) system that quantitatively characterizes protein–ligand interactions without user intervention and with minimal sample needs through protein-detected heteronuclear 2D NMR spectroscopy. Quantitation of protein...

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Detalles Bibliográficos
Autores principales: Plata, Marek, Sharma, Manvendra, Utz, Marcel, Werner, Jörn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912330/
https://www.ncbi.nlm.nih.gov/pubmed/36716203
http://dx.doi.org/10.1021/jacs.2c13052