The Combination of ATM and Chk1 Inhibitors Induces Synthetic Lethality in Colorectal Cancer Cells

SIMPLE SUMMARY: DNA damage response (DDR)-related proteins contribute to tumorigenesis, tumor progression, and drug resistance. Pharmacological inhibition of DDR-related proteins, such as checkpoint kinase 1 (Chk1), exerts antitumor effects but has serious side effects. Therefore, we attempted to sp...

Descripción completa

Detalles Bibliográficos
Autores principales: Tozaki, Yuri, Aoki, Hiromasa, Kato, Rina, Toriuchi, Kohki, Arame, Saki, Inoue, Yasumichi, Hayashi, Hidetoshi, Kubota, Eiji, Kataoka, Hiromi, Aoyama, Mineyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913148/
https://www.ncbi.nlm.nih.gov/pubmed/36765693
http://dx.doi.org/10.3390/cancers15030735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913148/
https://www.ncbi.nlm.nih.gov/pubmed/36765693
http://dx.doi.org/10.3390/cancers15030735

Ejemplares similares