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Current State and Future Challenges for PI3K Inhibitors in Cancer Therapy

SIMPLE SUMMARY: Phosphatidylinositol 3-kinase (PI3K) is a key regulator of many cellular processes and its hyperactivation promotes tumor cell growth and survival. A broad evaluation of the upstream and downstream nodes of its pathway allowed the discovery of several PI3K inhibitors (PI3Ki) with ant...

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Detalles Bibliográficos
Autores principales:	Sirico, Marianna, D’Angelo, Alberto, Gianni, Caterina, Casadei, Chiara, Merloni, Filippo, De Giorgi, Ugo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913212/ https://www.ncbi.nlm.nih.gov/pubmed/36765661 http://dx.doi.org/10.3390/cancers15030703

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