Inhibition of Checkpoint Kinase 1 (CHK1) Upregulates Interferon Regulatory Factor 1 (IRF1) to Promote Apoptosis and Activate Anti-Tumor Immunity via MICA in Hepatocellular Carcinoma (HCC)

SIMPLE SUMMARY: The communication between the DNA damage response pathway and the tumor microenvironment of hepatocellular carcinoma (HCC) has attracted more attention. In this study, high CHK1 expression in HCC tissue was associated with advanced tumor stage and poor prognosis in patients. CHK1 inh...

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Detalles Bibliográficos
Autores principales: Li, Xicai, Huang, Jingquan, Wu, Qiulin, Du, Qiang, Wang, Yingyu, Huang, Yubin, Cai, Xiaoyong, Geller, David A., Yan, Yihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913340/
https://www.ncbi.nlm.nih.gov/pubmed/36765808
http://dx.doi.org/10.3390/cancers15030850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913340/
https://www.ncbi.nlm.nih.gov/pubmed/36765808
http://dx.doi.org/10.3390/cancers15030850

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