DRP1 Inhibition Enhances Venetoclax-Induced Mitochondrial Apoptosis in TP53-Mutated Acute Myeloid Leukemia Cells through BAX/BAK Activation

SIMPLE SUMMARY: Poor response to venetoclax in TP53-mutated (TP53mut) acute myeloid leukemia (AML) is a clinical challenge. To develop more effective therapeutic strategies for this subset of AML with dismal prognosis, the molecular mechanism involved in the development of venetoclax resistance need...

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Detalles Bibliográficos
Autores principales: Jang, Ji Eun, Hwang, Doh Yu, Eom, Ju-In, Cheong, June-Won, Jeung, Hoi-Kyung, Cho, Hyunsoo, Chung, Haerim, Kim, Jin Seok, Min, Yoo Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913445/
https://www.ncbi.nlm.nih.gov/pubmed/36765703
http://dx.doi.org/10.3390/cancers15030745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913445/
https://www.ncbi.nlm.nih.gov/pubmed/36765703
http://dx.doi.org/10.3390/cancers15030745

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