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DRP1 Inhibition Enhances Venetoclax-Induced Mitochondrial Apoptosis in TP53-Mutated Acute Myeloid Leukemia Cells through BAX/BAK Activation
SIMPLE SUMMARY: Poor response to venetoclax in TP53-mutated (TP53mut) acute myeloid leukemia (AML) is a clinical challenge. To develop more effective therapeutic strategies for this subset of AML with dismal prognosis, the molecular mechanism involved in the development of venetoclax resistance need...
Autores principales: | Jang, Ji Eun, Hwang, Doh Yu, Eom, Ju-In, Cheong, June-Won, Jeung, Hoi-Kyung, Cho, Hyunsoo, Chung, Haerim, Kim, Jin Seok, Min, Yoo Hong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913445/ https://www.ncbi.nlm.nih.gov/pubmed/36765703 http://dx.doi.org/10.3390/cancers15030745 |
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