Nicotinaldehyde, a Novel Precursor of NAD Biosynthesis, Abrogates the Anti-Cancer Activity of an NAD-Lowering Agent in Leukemia

SIMPLE SUMMARY: Cancer cells are reliant on a sufficient amount of nicotinamide adenine nucleotide (NAD) to sustain their altered metabolism and proliferation. Targeting NAD depletion with inhibitors of NAD biosynthesis has therefore emerged as a promising approach for cancer treatment. Growing evid...

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Detalles Bibliográficos
Autores principales: Matsumoto, Saki, Biniecka, Paulina, Bellotti, Axel, Duchosal, Michel A., Nahimana, Aimable
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913462/
https://www.ncbi.nlm.nih.gov/pubmed/36765744
http://dx.doi.org/10.3390/cancers15030787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913462/
https://www.ncbi.nlm.nih.gov/pubmed/36765744
http://dx.doi.org/10.3390/cancers15030787

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