Phosphorylation of IGFBP-3 by Casein Kinase 2 Blocks Its Interaction with Hyaluronan, Enabling HA-CD44 Signaling Leading to Increased NSCLC Cell Survival and Cisplatin Resistance

Cisplatin is a platinum agent used in the treatment of non-small cell lung cancer (NSCLC). Much remains unknown regarding the basic operative mechanisms underlying cisplatin resistance in NSCLC. In this study, we found that phosphorylation of IGFBP-3 by CK2 (P-IGFBP-3) decreased its binding to hyalu...

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Detalles Bibliográficos
Autores principales: Coleman, Kai-ling, Chiaramonti, Michael, Haddad, Ben, Ranzenberger, Robert, Henning, Heather, Al Khashali, Hind, Ray, Ravel, Darweesh, Ban, Guthrie, Jeffrey, Heyl, Deborah, Evans, Hedeel Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913475/
https://www.ncbi.nlm.nih.gov/pubmed/36766747
http://dx.doi.org/10.3390/cells12030405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913475/
https://www.ncbi.nlm.nih.gov/pubmed/36766747
http://dx.doi.org/10.3390/cells12030405

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