Perturbation of Autophagy by a Beclin 1-Targeting Stapled Peptide Induces Mitochondria Stress and Inhibits Proliferation of Pancreatic Cancer Cells

SIMPLE SUMMARY: Autophagy has long been regarded as playing both pro- and anti-proliferative roles in many types of cancer, including PDAC. As the autophagy inhibitor CQ failed to show therapeutic efficacy in PDAC clinical trials, it is worth exploring whether the alternative approach, i.e., elevati...

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Detalles Bibliográficos
Autores principales: Li, Na, Zhang, Xiaozhe, Chen, Jingyi, Gao, Shan, Wang, Lei, Zhao, Yanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913477/
https://www.ncbi.nlm.nih.gov/pubmed/36765914
http://dx.doi.org/10.3390/cancers15030953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913477/
https://www.ncbi.nlm.nih.gov/pubmed/36765914
http://dx.doi.org/10.3390/cancers15030953

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